top of page

Publications

* Reprints are available, please contact Ioannis (ioz1(at)pitt.edu for any questions)

Link to Pubmed or Google Scholar

​​

  1. A. L. Scott, D. E. Jazwinska, D. G. Kulawiec, I. K. Zervantonakis. "Paracrine Ovarian Cancer Cell‐Derived CSF1 Signaling Regulates Macrophage Migration Dynamics in a 3D Microfluidic Model that Recapitulates in vivo Infiltration Patterns in Patient‐Derived Xenografts", Advanced Healthcare Materials, (2024)
     

  2. D. E. Jazwinska, Y. Cho, I.K. Zervantonakis. "Enhancing PKA-dependent mesothelial barrier integrity reduces ovarian cancer spheroid transmesothelial migration via inhibition of contractility", iScience (2024)
     

  3. [Pre-print] Y. Cho, M. Laird, T. Bishop, R. Li, E. Ruffo, J. Lohmueller, I.K. Zervantonakis. "CAR T cell infiltration and cytotoxic killing within the core of 3D breast cancer spheroids under control of antigen sensing in mocrowell arrays", bioRixiv (2024)
     

  4. [Pre-print] L. Sanghoon, Y. Cho, Y. Li, R. Li, D. Brown, P. McAuliffe, A.V. Lee, S. Oesterreich, I.K. Zervantonakis, H.U. Osmanbeyoglu. "Cancer-cell derived S100A11 promotes macrophage recruitment in ER+ breast cancer", bioRxiv (2024)
     

  5. M. Poskus, T. Wang, Y. Deng, S. Borcherding, J. Atkinson, I.K. Zervantonakis. "Fabrication of 3D-printed molds for polydimethylsiloxane-based microfluidic devices using a liquid crystal display-based vat photopolymerization process: printing quality, drug response and 3D invasion cell culture assays", Microsystems and Nanoengineering (2023)

    ​​

  6. M. Kalli, M. Poskus, T. Stylianopoulos, I.K. Zervantonakis. "Beyond matrix stiffness: targeting force-induced cancer drug resistance", Trends Cancer (2023)

    ​​

  7. D.E. Jazwinska, D.K. Kulawiec, I.K. Zervantonakis. "Cancer-mesothelial and cancer-macrophage crosstalk in the ovarian cancer microenvironment", Am J Physiol Cell Physiol (2023)
    ​

  8. M. Labrie, J.S. Brugge, G.B Mills, I.K. Zervantonakis. "Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer", Nature Reviews Cancer (2022)

    ​​

  9. N. Mohammad Mirzaei, Z. Tatarova, W. Hao, N. Changizi, A. Asadpoure, I.K. Zervantonakis, Y. Hu, Y.H. Chang, L. Shahriyari. "A PDE Model of Breast Tumor Progression in MMTV-PyMT Mice", Journal of Personalized Medicine, 12(5),807, (2022)
     

  10. N. Mohammad Mirzaei, N. Changizi, A. Asadpoure, S. Su, D. Sofia, Z. Tatarova, I.K. Zervantonakis, Y.H. Chang, L. Shahriyari. "Investigating key cell types and molecules dynamics in PyMT mice model of breast cancer through a mathematical model", PLoS Computational Biology, 18(3):e1009953, (2022)
     

  11. M. Kalli, R. Li, G.B. Mills, T. Stylianopoulos, I.K. Zernantonakis. "Mechanical stress signaling in pancreatic cancer cells triggers p38 MAPK- and JNK- dependent cytoskeleton remodeling and promotes cell migration via Rac1/Cdc42/Myosin II", Molecular Cancer Research, 20(3):485-497, (2021)
     

  12. N. Mohammad Mirzaei, S. Su, D. Sofia, M. Hegarty, M.H. Abdel-Rahman, A. Asadpoure, C.M. Cebulla, Y.H. Chang, W. Hao, P.R. Jackson, A.V. Lee, D.G. Stover, Z. Tatarova, I.K. Zervantonakis, L. Shahriyari. "A Mathemtatical Model of Breast Tumor Progression Based on Immune Infiltration", Journal of Personalized Medicine, 11(10), 1031, (2021)
     

  13. S. Hamalian, R. Guth, F. Runa, F. Sanchez, E. Vickers, M. Agajanian, J. Molnar, T. Nguyen, J. Gamez, J.D. Humphries, A. Nayak, M.J. Humphries, J. Tchou, I.K. Zervantonakis, J.A. Kelber. "A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for antiapoptotic and stress signaling markers", Oncogene, 40(33), 5224-5235, (2021)
     

  14. W. Zhao, J. Li, M.M. Chen, Y. Luo, Z. Ju, N.K. Nesser, K. Johnson-Camacho, C.T. Boniface, Y. Lawrence, N.T. Pande, M.A. Davis, M. Herlyn, T. Muranen, I.K. Zervantonakis, E. von Euw, A. Schultz, S.V. Kumar, A. Korkut, P.T. Spellman, R. Akbani, D.J. Salmon, J.W. Gray, J.S. Brugge, Y. Lu, G.B. Mills, H. Liang. "Large-Scale Characterization of Drug Responses of Clincially Relevant Proteins in Cancer Cell Lines", Cancer Cell, 38(6), 829-843, (2020)
     

  15. E. Nyman, R.R. Stein, X. Jing, W. Wang, B. Marks, I.K. Zervantonakis, A. Korkut, N.P. Gauthier, C. Sander. "Pertrubation biology links termporal proteins chagnes to drug responses in melanoma cell line", PLoS Biology, 16(7). e1007909. (2020)
     

  16. I.K. Zervantonakis, M.D. Poskus, A.L. Scott, L.M. Selfors, J. Lin, D.A. Dillon, S. Pathania, P.K. Sorger, G.B. Mills, J.S. Brugge. "Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways", PNAS, 117(28), 16500-16508. (2020)
     

  17. S. Correa, N. Boehnke, A.E. Barberio, E. Deiss-Yehiely, A. Shi, B. Oberlton, S.G. Smith, I.K. Zervantonakis, E.C. Dreaden and P.T. Hammond. "Tuning Nanoparticle Interactions with Ovarian Cancer through Layer by Layer Modification of Surface Chemistry", ACS Nano, 14(2), 2224-2237. (2020)
     

  18. S. Sarkizova, S. Klaeger, P.M. Le, L.W. Li, G. Oliveira, H. Keshishian, C.R. Hartigan, W. Zhang, D.A. Braun, K.L. Ligon, P. Bachireddy, I.K. Zervantonakis, J.M. Rosebluth, T. Ouspenskaia, T. Law, S. Justesen, J. Stevens, W.J. Lane, T. Eisenhaure, G.L. Zhang, K.R. Clauser, N. Hacohen, S.A. Carr, C.J. Wu and D.B. Keskin. “A Large Peptidome Dataset Improves HLA Class I Epitope Prediction across Most of the Human Population”, Nature Biotechnology, 38(2), 199-209. (2019)
     

  19. E.H. Stover, M.B. Baco, O. Cohen, Y.Y. Li, E.L. Christie, M. Bagul, A. Goodale, Y. Lee, S. Pantel, M.G. Rees, G. Wei, A.G. Presser, M.K. Gelbard, W. Zhang, I.K. Zervantonakis, P.D. Bhola, J. Ryan, J.L. Guerriero, J. Montero, F.J. Liang, A.D. Cherniack, F. Piccioni, U.A. Matulonis, D.D.L. Bowtell, K.A. Sarosiek, A. Letai, L.A. Garraway, C.M. Johannssen and M. Meyerson. "Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer", Molecular Cancer Research, 17(11), 2281-2293. (2019)
     

  20. C. Iavarone, I.K. Zervantonakis, L.M. Selfors, S. Palakurthi, J.F. Liu, R. Drapkin, D. Sampath, G.B. Mills and J.S. Brugge. "Combined MEK and Bcl-2/XL inhibition is effective in high-grade serous ovarian cancer patient–derived xenograft models and BIM levels are predictive of responsiveness", Molecular Cancer Therapeutics, 18(3), 642-655. (2019)​
     

  21. A.K. Mookhtiar, P. Greninger, R.J. March, R.K. Egan, H.S. Luu,I.K. Zervantonakis,A. Najafov, D.G. Stover, U.A. Matulonis, C.H. Benes, J. Yuan. “BRAF and AXL oncogenes drive RIPK3 expression loss in cancer”, PLoS Biology 16(8). e20005756. (2018)
     

  22. I.K. Zervantonakis, C. Iavarone, H.S. Chen, L.M. Selfors, S. Palakurthi, J.F. Liu, R. Drapkin,  U. Matulonis, J.D. Leverson, D. Sampath, G.B. Mills and J.S. Brugge. "Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response", Nature Communications 8(1): 365 (2017)
     

  23. K. Funamoto, D. Yoshino, K. Matsubara, I.K. Zervantonakis, K. Funamoto, M. Nakayama, J. Masamune, Y. Kimura, R.D. Kamm. “Endothelial monolayer permeability under controlled oxygen tension”, Integrative Biology 9: 529-538 (2017)
    ​

  24. J.F. Liu, S. Palakurthi, Q. Zeng, S. Zhou, E. Ivanova, W. Huang, I.K. Zervantonakis, L.M. Selfors, Y. Shen, C. Pritchard, M. Zheng, V Adleff, E. Papp, H. Piao, M. Novak, S. Fotheringham, G. Wulf, J. English, P.T. Kirschmeier, V. Velculescu, C. Paweletz, G.B. Mills, D.M. Livingston, J.S. Brugge, U.A. Matulonis, R. Drapkin. “Establishment of patient-derived tumor xenograft models of epithelial ovarian cancer for pre-clinical evaluation of novel therapeutics”, Clinical Cancer Research 23 (5): 1263-1273 (2017)
     

  25. I.K. Zervantonakis & C.D. Arvanitis. "Controlled Drug Release and Chemotherapy Response in a novel 3D Acoustofluidic Platform", Small 12 (19), 2616-2626 (2016)
     

  26. T. Kobus, I.K. Zervantonakis, Y. Zhang and N.J. McDannold. "Growth inhibition in a brain metastasis model by antibody delivery using focused ultrasound-mediated blood-brain barrier disruption", Journal of Controlled Release 238: 281-288. (2016) 
     

  27. M.P. Iwanicki, H.Y. Chen, C. Iavarone, I.K. Zervantonakis, T. Muranen, M. Novak, T.A. Ince, R. Drapkin, J.S. Brugge. "Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition", JCI Insight 1 (10) (2016)
     

  28. L. Gallegos, R. Ng, M. Sowa, L. Selfors, A. White, I.K. Zervantonakis, P. Singh, S. Dakal, W. Harper, J.S. Brugge . “A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin” Scientific Reports 6, srep27114 (2016)
     

  29. A. Spiegel, M.W. Brooks, S. Houshyar, F. Reinhardt, M. Ardolino, E. Fessler, M.B. Chen, J.A. Krall, J. DeCock, I.K. Zervantonakis, A. Iannello, Y. Iwamoto, V Cortez-Retamozo, R.D. Kamm, M.J. Pittet, D.H. Raulet, R.A. Weinberg. “Neutrophils suppress intraluminal NK-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells” Cancer Discovery 6 (6): 630-649 (2016)
     

  30. I. Kandela and I.K. Zervantonakis. "Registered report: Discovery and preclinical validation of drug indications using compendia of public gene expression data" eLife 4: e06847 (2015)
     

  31. A. Pavesi, G. Adriani, M. Rasponi, I.K. Zervantonakis, G.B. Fiore, & R.D. Kamm. Controlled electromechanical cell stimulation on-a-chip. Scientific reports, 5. (2015)
     

  32. P. Parthasarathy, I.K. Zervantonakis and C. R. Kothapalli. “Synergistic effects of 3D ECM and Chemogradients on Neurite Outgrowth and Guidance: A Simple Modeling and Microfluidic Framework”, PLoS One, 9 (6) e99640. (2014)
     

  33. T.K. Schuessler, X.Y. Chan, H.J. Chen, K. Ji, K.M. Park, A. Roshan-Ghias, P. Sethi, A. Thakur, X. Tian, A. Villasante, I.K. Zervantonakis, N.M. Moore, L. Nagahara, N.Z. Kuhn. Biomimetic Tissue-Engineered Systems for Advancing Cancer Research: NCI Strategic Workshop Report. Cancer Research 74, 5359-5363, (2014)
     

  34. W.J. Polacheck, I.K. Zervantonakis and R. D. Kamm . "Tumor cell migration in complex microenvironments", Cellular and Molecular Life Sciences, 70 (8), 1335-1356. (2013)
     

  35. J.S. Jeon, I. K. Zervantonakis, S. Chung, R.D. Kamm and J.L. Charest. "In Vitro Model of Tumor Cell Extravasation" PLoS One,  8 (2) e56910. (2013)
     

  36. I.K. Zervantonakis, S. K. Alford-Hughes, J. L. Charest, F. B. Gertler, J. C. Condeelis and R. D. Kamm. "Three-dimensional microfluidic tumor-vascular interface model: Tumor cell intravasation and endothelial barrier function." PNAS, 109 (34), 13515-13520. (2012)
     

  37. K. Funamoto, I.K. Zervantonakis, Y. Liu, C. Ochs, C. Kim and R. D. Kamm. "A Novel Microfluidic Platform for High-Resolution Imaging of a Three-Dimensional Culture under a Controlled Hypoxic Environment", Lab on Chip, 12 (22), 4855-63. (2012)
     

  38. A.R. Aref, R. Huang, W. Yu, K.-N. Chua, W. Sun, T.-Y. Tu, J. Bai, I. K. Zervantonakis, J. P. Thiery and R. D. Kamm. "Screening therapeutic EMT blocking agents in a three-dimensional microenvironment" Integrative Biology, 5 (2), 381-389. (2012)
     

  39. J.M. Chan, I. K. Zervantonakis, T. Rimchala, W.J. Polacheck, J. Whisler and R. D. Kamm. "Engineering of In Vitro 3D Capillary Beds by Self-Directed Angiogenic Sprouting" PLoS One,  7 (12) e50582. (2012)
     

  40. Shin, Y., S. Han, J. S. Jeon, K. Yamamoto, I. K. Zervantonakis, R. Sudo, R. D. Kamm and S. Chung. "Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels." Nature Protocols, 7(7), 1247-59. (2012)
     

  41. W.A. Farahat, L.B. Wood, I.K. Zervantonakis, A. Schor, S. Ong, D. Neal, R.D. Kamm and H.H. Asada. "Ensemble Analysis of Angiogenic Growth in Three-Dimensional Microfluidic Cell Cultures." PLoS One,  (5), e37333. (2012)
     

  42. C.K. Kothapali, E. van Veen, S. de Valence, S. Chung, I.K. Zervantonakis, F. Gertler, R. Kamm. “A High-throughput Microfluidic Assay to Study Axonal Response to Growth Factor Gradients”. Lab On Chip, 11, 497-507. (2011)
     

  43. Y. Luo, I.K. Zervantonakis, S. Baek Oh, R.D. Kamm, G. Barbastathis. “Spectrally resolved multidepth fluorescence imaging”, J. Biomed. Opt. 16, 096015. (2011)
     

  44. I.K. Zervantonakis, C.K. Kothapali, S. Chung, R. Sudo, R.D. Kamm. “Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments”. Biomicrofluidics, 5(1): 13406. (2011)
     

  45. S. Chung, R. Sudo, V. Vickerman, I.K. Zervantonakis, R. Kamm. “Microfluidic Platforms for Studies of Angiogenesis, Cell Migration, and Cell-Cell Interactions”. Annals of Biomedical Engineering, 38 (3), 1164-1177. (2010)
     

  46. I.K. Zervantonakis, S. Chung, R. Sudo, M. Zhang, J. Charest, R. Kamm. “Concentration gradients in microfluidic 3D matrix cell culture systems”. International Journal on Micro-Nano Scale Transport, 1 (1), 27-36. (2010)
     

  47. R. Sudo, S. Chung, I.K. Zervantonakis, V. Vickerman, Y. Toshimitsu, L. Griffith, R. Kamm “Transport-mediated angiogenesis in 3D epithelial coculture”. FASEB J. 23(7), 2155-64. (2009)
     

  48. S. Chung, R. Sudo, I.K. Zervantonakis, T. Rimchala, R. Kamm. “Surface-Treatment-Induced Three-Dimensional Capillary Morphogenesis in a Microfluidic Platform”. Advanced Materials, 21 (47), 4863-4867. (2009)
     

  49. S.K. Das, S. Chung, I.K. Zervantonakis, J. Atnafu, R. Kamm “A microfluidic platform for studying the effects of small temperature gradients in an incubator environment”. Biomicrofluidics 2, 034106. (2008)
     

  50. I. K. Zervantonakis, W-N. Lee, S.D. Fung-Kee-Fung and E. E. Konofagou. “A novel view-independent strain estimation method in myocardial elastrography: Eliminating angle- and centroid-dependence”, Physics in Medicine and Biology 52, pp. 4063-4080. (2007)

bottom of page